Emmanuelle Charpentier

The cost-benefit trade-off of peritrichous flagellation in bacteria

This study quantifies the cost-benefit trade-off of peritrichous flagellation in Salmonella enterica, showing that increased flagellation reduces growth rate but enhances motility and competitive fitness in structured environments.

Stress-induced ribosome degradation in Bacillus subtilis is mediated by the RNase Y-specificity complex

The paper identifies the Y-complex as a regulator of RNase Y specificity in Bacillus subtilis, showing it mediates stress-induced ribosome degradation by targeting rRNA.

Microbiota-induced fatty acid synthesis facilitates intestinal infection and immune-mediated damage in Drosophila

This study shows that gut microbiota, specifically Lactiplantibacillus plantarum, enhances fatty acid synthesis in Drosophila, promoting pathogen virulence and immune-mediated damage.

Novel RNA-binding protein YebC enhances translation of proline-rich amino acid stretches in bacteria

The paper identifies YebC as a novel translation factor in S. pyogenes that enhances translation of proline-rich amino acid stretches.

Bacterial motility depends on a critical flagellum length and energy-optimised assembly

This study shows that bacterial flagellum assembly is optimized for energy efficiency and motility by balancing secretion rate and filament length.

The energy metabolism of Cupriavidus necator in different trophic conditions

This study investigates the energy metabolism of Cupriavidus necator under different trophic conditions by analyzing gene fitness using a barcoded transposon knockout library, revealing substrate-specific enzyme utilization and gene redundancy.

Dynamics of diversified A-to-I editing in Streptococcus pyogenes is governed by changes in mRNA stability

The paper identifies A-to-I editing in Streptococcus pyogenes, showing it diversifies and is regulated by mRNA stability in response to infection-related stimuli.

Expanding the genetic toolbox for the obligate human pathogen Streptococcus pyogenes

This study develops a comprehensive genetic toolbox for Streptococcus pyogenes, including plasmids, promoters, and reporters, to facilitate gene function studies and virulence mechanism analysis.

A regulatory toolkit of arabinose-inducible artificial transcription factors for Gram-negative bacteria

The paper develops arabinose-inducible artificial transcription factors for Gram-negative bacteria to control gene expression and demonstrates their use in biosensor and metabolic engineering applications.