Yuhai Tu

Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli

This study shows that chromosomal topological domains in E. coli repress transcription, reduce orientation effects, and modulate gene coupling through supercoiling changes.

Subunit shuffling dynamics in KaiC's central hub reveal the synchronization mechanism of the cyanobacterial circadian clock

The paper investigates subunit shuffling dynamics in KaiC's central hub, revealing how ATPase activity regulates this process in the cyanobacterial circadian clock.

Bacterial motility depends on a critical flagellum length and energy-optimised assembly

This study shows that bacterial flagellum assembly is optimized for energy efficiency and motility by balancing secretion rate and filament length.

Neurons exploit stochastic growth to rapidly and economically build dense radially oriented dendritic arbors

The paper develops a mean-field model showing stochastic growth can create complex dendritic arbors without external guidance.

Effects of short-term plasticity in early olfactory information processing in Drosophila

The paper develops a circuit model of olfactory processing in Drosophila that incorporates short-term plasticity and presynaptic inhibition to explain divisive normalization and adaptation in PN responses.

Deciphering gene regulation from gene expression dynamics using deep neural network

This paper uses a deep neural network to infer gene regulation networks from gene expression dynamics, demonstrating its ability to predict mutant behaviors and uncover regulatory mechanisms.

The optimal odor-receptor interaction network is sparse in olfactory systems: Compressed sensing by nonlinear neurons with a finite dynamic range

The paper shows that the optimal odor-receptor interaction network is sparse and follows a log-normal distribution, enhancing decoding accuracy in olfactory systems.

Deciphering the regulation mechanism in biochemical networks by a systems-biology approach

The paper develops a network model to analyze the regulation of histidine kinase CheA by chemoreceptors, revealing a dual regulation mechanism involving ATP binding and P1 binding or phosphotransfer.