Shuibing Chen

MUTUAL enables cross-modality analysis between transcriptome and chromatin by learning a shared RNA-ATAC space from multiome data without refitting.

The paper integrates multiple scRNA-seq datasets to create a comprehensive atlas of human pancreatic islets, identifying 13 cell populations and providing a resource for diabetes research.

This paper describes a scalable method to differentiate human pluripotent stem cells into hypothalamic arcuate neurons, which can model metabolic and reproductive disorders.

This paper develops a pacemaker-driven human mini-heart using spatial multi-omics and stem-cell engineering to study cardiac conduction and drug discovery.

This study shows that pluripotency factors in hESCs regulate negative interferon regulators, suppressing interferon signaling to maintain pluripotency while preserving antiviral resistance.

Genipin rescues developmental and degenerative defects in familial dysautonomia and enhances neuron regeneration after injury.

The paper develops a knowledge graph framework to extract biomedical knowledge from PubMed, creating a database that enhances transparency in biomedical AI applications.

This paper develops a basecalling scheme for short-read nanopore sequencing, showing improved accuracy using bioengineered RNA molecules.

The paper develops vascularized macrophage-islet organoids to study immune-mediated β cell pyroptosis during viral infection and identifies TNFSF12-TNFRSF12A as a key mechanism.

This study uses single-cell RNA sequencing to analyze gene expression changes in human pancreatic islets under different glucose conditions over 24 hours, identifying genes and modules associated with time, glucose exposure, and their interaction.

This study identifies a drug cocktail that accelerates maturation of hPSC-derived neurons and other cell types through pharmacological intervention.

This study functionally interrogates 20 T2D-associated genes using isogenic hESC-derived β-like cells, identifying variants and genes linked to insulin production and lipotoxicity sensitivity.

This study derives Schwann cells from human pluripotent stem cells to model diabetic peripheral neuropathy and identify a drug candidate that rescues sensory function and prevents myelin damage.

This study integrates single-cell gene expression and chromatin accessibility data from human pancreatic islets to identify T1D risk mechanisms involving multiple cell types and genetic variants.

This study identifies and characterizes hPSC-derived FOXA2+ progenitor cells with enhanced ventricular cardiomyocyte differentiation potential.