Brad R. Rosenberg

Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration

B cells sustain tumor-specific CD4 T cells to promote response to PD-1 targeted therapy

This study shows that B cells support tumor-specific CD4 T cells to enhance PD-1 blockade efficacy, but antibody secretion is not necessary for long-term survival.

The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell intrinsic control of endosomal dynamics

This study identifies USP7 as a gene that restricts neurotropic orthoflavivirus entry by controlling endosomal dynamics, with mutations in USP7 increasing susceptibility to ZIKV infection.

Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon

The paper characterizes gene regulatory networks in human airway epithelial cells and identifies cell type-specific responses to type I interferon.

Pluripotency Factors Modulate Interferon Signaling in Embryonic Stem Cells

This study shows that pluripotency factors in hESCs regulate negative interferon regulators, suppressing interferon signaling to maintain pluripotency while preserving antiviral resistance.

An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma

This study develops an immunocompetent mouse model of virus-induced liver fibrosis and hepatocellular carcinoma using Norway rat hepacivirus.

Broad-spectrum RNA antiviral inspired by ISG15-/- deficiency

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

ICOS limits memory-like properties and function of exhausted PD-1+ CD8 T cells

This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.