Jeongkyung Lee

This study shows hepatocyte TEAD1 promotes fibrosis and inflammation in cholestatic liver injury but not bile acid metabolism, suggesting it as a therapeutic target in PSC.

This study identifies TEAD1 as a direct regulator of NRF2 and oxidative stress response in cardiomyocytes, showing its critical role in maintaining antioxidant defenses and its downregulation in heart failure.

This study shows that BET inhibitor I-BET protects β-cells from cytokine-induced death and dysfunction by inhibiting NF-κB signaling and preserving key β-cell genes.

This study shows TEAD1 regulates adult β-cell proliferation and function, maintaining glucose homeostasis by balancing quiescence and mature identity in mice and humans.