Author

Rajaganapathi Jagannathan

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Mousumi MoulikiD· 2 shared Aine N. Boudreau· 1 shared Amy Isabella SentisiD· 1 shared Anita P. SarafiD· 1 shared Bill B. CheniD· 1 shared Brent Schlegel· 1 shared Dhivyaa RajasundaramiD· 1 shared Dominic Woods· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Mousumi MoulikORCID

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2 papers

Recent·Most cited

TEAD1 is a novel regulator of NRF2 and oxidative stress response in cardiomyocytes

Rajaganapathi Jagannathan, Jeongkyung Lee, Evan DeVallance, Vinny Negi, Varun Mandi, Hridyanshu Vyas, Feng Li, Patrick J. Pagano, Vijay K. Yechoor, Mousumi Moulik

This study identifies TEAD1 as a direct regulator of NRF2 and oxidative stress response in cardiomyocytes, showing its critical role in maintaining antioxidant defenses and its downregulation in heart failure.

bioRxiv · Apr 6, 2025 · PreprintMolecular Biology

Hypomorphic NOTCH1 Expression Alters Cardiomyocyte Cellular Architecture in Hypoplastic Left Heart Syndrome

Jordann Lewis, Travis B. Lear, Brent Schlegel, Dominic Woods, Krithika Rao, Amy Isabella Sentis, Jay Xiaojun Tan, Rajaganapathi Jagannathan, Zaineb Javed, Aine N. Boudreau, Timothy J. Nelson, Mousumi Moulik, Nadine Hempel, Bill B. Chen, Sruti Shiva, , Anita P. Saraf

This paper uses CRISPR-edited human iPSCs with hypomorphic NOTCH1 to model hypoplastic left heart syndrome, identifying auranofin as a potential therapeutic.

bioRxiv · Sep 30, 2024 · PreprintCell Biology