Author

Varun Mandi

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Jeongkyung LeeiD· 3 shared Mousumi MoulikiD· 3 shared Vijay K. YechooriD· 3 shared Vinny NegiiD· 3 shared Domenic FilingeriiD· 2 shared Feng LiiD· 2 shared Amit KumariD· 1 shared Eliana Melissa Perez-GarciaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMolecular Biology

Jeongkyung LeeORCID

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3 papers

Recent·Most cited

Hepatocyte TEAD1 drives epithelial-stromal remodeling during cholestatic liver injury

Kumar Ar, Jeongkyung Lee, Vinny Negi, Varun Mandi, Domenic Filingeri, Joey Danvers, Rajat Pant, Samit Ghosh, Mousumi Moulik, Vijay K. Yechoor

This study shows hepatocyte TEAD1 promotes fibrosis and inflammation in cholestatic liver injury but not bile acid metabolism, suggesting it as a therapeutic target in PSC.

bioRxiv · May 26, 2026 · PreprintPathology

TEAD1 is a novel regulator of NRF2 and oxidative stress response in cardiomyocytes

Rajaganapathi Jagannathan, Jeongkyung Lee, Evan DeVallance, Vinny Negi, Varun Mandi, Hridyanshu Vyas, Feng Li, Patrick J. Pagano, Vijay K. Yechoor, Mousumi Moulik

This study identifies TEAD1 as a direct regulator of NRF2 and oxidative stress response in cardiomyocytes, showing its critical role in maintaining antioxidant defenses and its downregulation in heart failure.

bioRxiv · Apr 6, 2025 · PreprintMolecular Biology

Bromodomain protein inhibition protects β-cells from cytokine-induced death and dysfunction via antagonism of NF-κB pathway.

Vinny Negi, Jeongkyung Lee, Varun Mandi, Joseph Danvers, Ruya Liu, Eliana Melissa Perez-Garcia, Feng Li, Rajaganapati Jagannathan, Ping Yang, Domenic Filingeri, Amit Kumar, Ke Ma, Mousumi Moulik, Vijay K. Yechoor

This study shows that BET inhibitor I-BET protects β-cells from cytokine-induced death and dysfunction by inhibiting NF-κB signaling and preserving key β-cell genes.

Cells · Jun 26, 2024Peer-reviewedMolecular Biology