Vijay Ramaswamy

Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases

This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.

Ependymomas are cancers of the pre-neural crest/roof plate lineage

The paper identifies ependymomas as originating from the pre-neural crest/roof plate lineage using single-cell transcriptomics and lineage tracing.

hTERT Expression, Regulation, and Prognostic Significance in Pediatric Medulloblastoma

This study examines hTERT expression and its prognostic impact in pediatric medulloblastoma, finding higher expression correlates with worse survival outcomes.

Targeting synthetic lethality between non-homologous end joining and radiation in very high-risk SHH medulloblastoma

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres

This study shows that valproic acid reduces medulloblastoma cell viability and affects stemness, differentiation, and gene expression through histone acetylation changes.

Childhood cerebellar tumors mirror conserved fetal transcriptional programs

The paper uses single-cell transcriptomics to show childhood cerebellar tumors mirror fetal cerebellar cell lineages, linking tumor subtypes to specific developmental stages.