Molecular BiologybioRxivPreprint
Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration
Soah Lee, Alison Schroer Vander Roest, Cheavar A. Blair…·Daniel Bernstein
This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.