Repurposing Melatonin in dual-mode for Wilson disease therapy as a Copper Chelator and an antioxidant agent
Raviranjan Pandey, Arpan Narayan Roy, Sandip Sarkar, Rakiba Rohman, Kaustav Chakraborty, Rupa Bargakshatriya, Sanjana Pandey, Pruthwiraj, Debosmita Bhattacharya, Saurav Kumar, Saptarshi Maji, Aidan T. Pezacki, Sumit Kumar Pramanik, Christopher J. Chang, Ashima Bhattacharjee, , Arnab Gupta
This paper evaluates melatonin as a dual-function therapeutic for Wilson disease, showing it reduces copper toxicity and oxidative stress in vitro and in vivo.
bioRxiv · Aug 30, 2025 · PreprintCell Biology