Synthetic chaperone based on Hsp90-Tau interaction inhibits pathological Tau aggregation and rescues physiological Tau-Microtubule interaction
Davide Di Lorenzo, Nicolò Bisi, Julia Kaffy, Lisa Marie Ramirez, Markus Zweckstetter, Olivier Lequin, Irene Garfagnini, Jinghui Luo, Yvonne Hannappel, Inga Ennen, Veronica Isabel Dodero, Norbert Sewald, Maria Luisa Gelmi, Nicolò Tonali, Roland Brandt, Sandrine Ongeri
This paper designs a synthetic peptide mimicking Hsp90-Tau interaction to inhibit Tau aggregation and restore its microtubule binding, showing efficacy in vitro and in cells.
Nature Communications · Oct 1, 2025Peer-reviewedPharmacology & Toxicology