Thomas R. Weikl

This study develops a model explaining how nanometre-scale changes in receptor dimensions affect CAR-T cell antigen sensitivity by linking physical principles to experimental observations.

This paper investigates the conformational dynamics of plasmepsin X during inhibitor binding and unbinding using molecular dynamics simulations, revealing a dominant unbinding pathway involving flap conformational changes.

The paper investigates how spherical nanoparticles or virus-like particles induce membrane tubulation through cooperative wrapping, showing that this process is energetically favorable due to interplay between bending and adhesion energies.

This paper investigates the allosteric mechanism of GPCRs, finding that both peptide- and small-molecule-activated GPCRs use an induced-fit mechanism rather than conformational selection.

This study uses simulations to analyze the conformational changes and elasticity of Piezo proteins in membrane nanodomains under tension, finding a half-maximal reduction of excess area at 3-4 mN/m tension.

The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.

The paper compares the stability of cellulose Iβ and II crystals by analyzing electrostatic, van der Waals, and hydrogen-bond interactions using classical force fields.