Developmental BiologyJOR SpinePeer-reviewed
A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain via Notochordal Cell Loss and Pain-inducing Nucleus Pulposus Cell Emergence
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez…·Dmitriy Sheyn
This study develops a porcine model of intervertebral disc injury that mimics human discogenic pain through notochordal cell loss and nucleus pulposus cell emergence, validated by MRI, biobehavioral testing, and single-cell transcriptomics.
DOI 10.1002/jsp2.70200