Author

Jacob T. Wechsler

Cedars-Sinai Medical CenterORCID 0009-0003-0770-4801Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:plant (other)· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Dmitriy SheyniD· 2 shared Giselle KanedaiD· 2 shared Julia Sheyn· 2 shared Pablo AvalosiD· 2 shared Candace L. FloydiD· 1 shared Chloe M. CastanedaiD· 1 shared Christopher N. JohnsoniD· 1 shared Chushu SheniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersDevelopmental Biology

Dmitriy SheynORCID

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2 papers

Recent·Most cited

Developmental BiologyJOR SpinePeer-reviewedJul 9, 2026

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain via Notochordal Cell Loss and Pain-inducing Nucleus Pulposus Cell Emergence

Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez…·Dmitriy Sheyn

This study develops a porcine model of intervertebral disc injury that mimics human discogenic pain through notochordal cell loss and nucleus pulposus cell emergence, validated by MRI, biobehavioral testing, and single-cell transcriptomics.

DOI 10.1002/jsp2.70200

plant (other)bulk RNA-seq

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Molecular BiologybioRxivPreprintMar 2, 2023

Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back pain

Wensen Jiang, Juliane D. Glaeser, Giselle Kaneda…·Dmitriy Sheyn

The paper identifies a stress-induced subtype of nucleus pulposus cells in degenerating intervertebral discs that trigger discogenic low back pain.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky