Giselle Kaneda

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain via Notochordal Cell Loss and Pain-inducing Nucleus Pulposus Cell Emergence

This study develops a porcine model of intervertebral disc injury that mimics human discogenic pain through notochordal cell loss and nucleus pulposus cell emergence, validated by MRI, biobehavioral testing, and single-cell transcriptomics.

Single Cell Proteomics Reveals Novel Cell Phenotypes in Marfan Mouse Aneurysm

This paper uses single-cell proteomics to identify novel cell phenotypes in Marfan mouse aorta, revealing sex differences and angiotensin signaling roles in aneurysm formation.

Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back pain

The paper identifies a stress-induced subtype of nucleus pulposus cells in degenerating intervertebral discs that trigger discogenic low back pain.

Single-cell Atlas Unveils Cellular Heterogeneity and Novel Markers in Human Neonatal and Adult Intervertebral Discs

The paper generates and compares single-cell atlases of human neonatal and adult intervertebral discs to identify cellular heterogeneity, sub-populations, and developmental trajectories.