Author

Akiko Iguchi‐Manaka

University of TsukubaORCID 0000-0002-0338-130XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Akira ShibuyaiD· 1 shared Chigusa Nakahashi-OdaiD· 1 shared Eri SugiyamaiD· 1 shared Genki OkumuraiD· 1 shared Hideaki TaharaiD· 1 shared Kazuko ShibuyaiD· 1 shared Naoto Takeuchi· 1 shared Natsuki Ide· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Akira ShibuyaORCID

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintMay 19, 2026

Soluble CD155 immune complexes reprogram DNAM-1 signaling to potentiate antitumor immunity

Shota Kinoshita, Tomohei Matsuo, Naoto Takeuchi…·Kazuko Shibuya

This paper identifies soluble CD155 as a systemic checkpoint that suppresses DNAM-1 signaling, leading to resistance to immune checkpoint inhibitors, and shows that an anti-sCD155 antibody can reprogram this signaling to enhance antitumor immunity.

DOI 10.64898/2026.05.16.725599

humanproteomics

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