Author

Pranavi Garlapati

The University of Texas at AustinORCID 0000-0002-0338-9053Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:electrophysiology· 2 Approach:experimental assay· 2 Organism:Xenopus· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Cecilia M. BorgheseiD· 2 shared Marcel P Goldschen-OhmiD· 2 shared Netrang G DesaiiD· 2 shared Christopher A. AherniD· 1 shared Erik R. LindahliD· 1 shared Harold H. ZakoniD· 1 shared Jason D. GalpiniD· 1 shared Luthary SeguraiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Cecilia M. BorgheseORCID

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2 papers

Recent·Most cited

Introducing a proline in the α1 M2-M3 linker relieves a molecular brake on channel activation in α1β2γ2 GABAA receptors

Netrang G Desai, Pranavi Garlapati, Cecilia M. Borghese, Marcel P Goldschen-Ohm

This study shows introducing a proline at site 2 in the α1 M2-M3 linker of GABAARs enhances GABA-sensitivity and spontaneous activity, suggesting it relieves a molecular brake on channel activation.

PLoS ONE · Sep 8, 2026Peer-reviewedBiophysics

An atomic interaction conserved for over 600 million years gates inhibitory neurotransmission

Cecilia M. Borghese, Netrang G Desai, Pranavi Garlapati, Syedah K Shah, Jason D. Galpin, Luthary Segura, Nandan Haloi, Harold H. Zakon, Rebecca J. Howard, Erik R. Lindahl, Christopher A. Ahern, Marcel P Goldschen-Ohm

The paper identifies a conserved atomic interaction in inhibitory neurotransmitter receptors that stabilizes channel gating and explains disease-linked mutations.

bioRxiv · May 26, 2026 · PreprintBiophysics