Author
The University of Texas at AustinORCID 0009-0001-5807-1413Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Netrang G Desai, Pranavi Garlapati, Cecilia M. Borghese, Marcel P Goldschen-Ohm
This study shows introducing a proline at site 2 in the α1 M2-M3 linker of GABAARs enhances GABA-sensitivity and spontaneous activity, suggesting it relieves a molecular brake on channel activation.
Cecilia M. Borghese, Netrang G Desai, Pranavi Garlapati…·Marcel P Goldschen-Ohm
The paper identifies a conserved atomic interaction in inhibitory neurotransmitter receptors that stabilizes channel gating and explains disease-linked mutations.
Cecilia M. Borghese, Jason D. Galpin, Samuel Eriksson Lidbrink…·Marcel P Goldschen-Ohm
The paper identifies a single main-chain hydrogen bond in the β2 subunit M2-M3 linker that inhibits GABAA receptor pore opening and is required to keep the unliganded channel closed.