An atomic interaction conserved for over 600 million years gates inhibitory neurotransmission
Cecilia M. Borghese, Netrang G Desai, Pranavi Garlapati, Syedah K Shah, Jason D. Galpin, Luthary Segura, Nandan Haloi, Harold H. Zakon, Rebecca J. Howard, Erik R. Lindahl, Christopher A. Ahern, Marcel P Goldschen-Ohm
The paper identifies a conserved atomic interaction in inhibitory neurotransmitter receptors that stabilizes channel gating and explains disease-linked mutations.
bioRxiv · May 26, 2026 · PreprintBiophysics