Michael D. Edge

This study investigates uncertainty in sibling-based GWAS allelic effect estimates and proposes a resampling-based method that is more accurate than existing approaches.

This paper introduces a method to reduce false positives in phylogenetic regression by incorporating eigenvectors of the phylogenetic variance-covariance matrix and presents a new R package for visualization.

This paper introduces a method using genetic relatedness matrices to control genetic confounding in observational studies, showing improved performance over existing approaches in smaller datasets.

This study uses an agent-based model to simulate metabolic signaling oscillations in Bacillus subtilis biofilms, showing how cellular properties drive collective behavior and nutrient distribution.

This paper shows that the likelihood ratios from IBDGem test a null hypothesis different from the traditional forensic one, potentially overestimating evidence strength for identity.

This paper introduces DR EVIL, a method to estimate mutation rates and demographic history from large haploid genome datasets, revealing mutation-rate heterogeneity and the impact of multiple mutation events on rare variants.

This paper introduces a likelihood-based framework called gLike to infer demographic history from genealogical trees, showing improved accuracy in estimating population parameters compared to existing methods.

This study shows that error rates in QST-FST comparisons depend on genetic architecture and estimation procedures, with some methods leading to high type I error rates.

The paper benchmarks ARG estimation methods for their performance in estimating population-mean polygenic score histories using simulated data.

This paper introduces PGSUS, a method to assess the influence of stratification and assortative mating effects on polygenic scores, revealing that direct genetic effects often contribute little to PGS variation.

This study examines how varying case fractions in case-control GWAS affects statistical power by analyzing mathematical bounds on r2 and the chi-squared noncentrality parameter.

This paper unifies statistical genetics and phylogenetics by developing a general model for genetic covariance, showing how GWAS and phylogenetic regression are special cases and demonstrating improved association testing through shared methodology.

The paper shows that within-group heritability cannot determine the genetic vs. environmental basis of between-group phenotypic differences, using mathematical analysis and simulations.

This paper introduces a QTL mapping method using expected local genetic relatedness matrices derived from ancestral recombination graphs, improving detection of QTLs in populations with limited imputation resources.

The paper identifies amplification as the main mechanism of gene-by-sex interactions in complex human traits, showing sex differences in genetic effect magnitudes rather than variant identity.

The paper finds that CODIS STR markers are located in regions with higher densities of trait-associated variants compared to other STRs.

This paper demonstrates how uploading genomes to genealogical databases can reveal private genetic information through IBS matching attacks.

The paper analyzes the success probability of long-range forensic familial searching using theoretical calculations and discusses its implications for the Golden State Killer case.

The paper shows linkage disequilibrium can identify relatives using nonoverlapping genetic markers, with 30-36% accuracy for parent-offspring and sib pairs.