Richard T. Osgood

Disruption of a Structural Niche for Otoconia Maintenance May Underlie Common Vestibular Disorders

The paper identifies a structural niche in the inner ear responsible for otoconia maintenance and links its disruption to vestibular disorders.

PKHD1L1 is required for stereocilia bundle maintenance, durable hearing function and resilience to noise exposure.

This study shows PKHD1L1 is essential for maintaining stereocilia bundles, hearing function, and resilience to noise in mice, with loss leading to age-related hearing loss and susceptibility to noise damage.

Large-scale annotated dataset for cochlear hair cell detection and classification

The paper presents a large annotated dataset of cochlear hair cells for machine learning applications in hearing research.

SKOOTS: Skeleton oriented object segmentation for mitochondria

SKOOTS segments mitochondria in 3D imaging data efficiently, revealing structural changes not detectable with existing methods.

The Hair Cell Analysis Toolbox: A machine learning-based whole cochlea analysis pipeline

The paper introduces HCAT, a machine learning tool for automated analysis of hair cells in cochlear images, enabling fast and unbiased counting, classification, and cochleogram generation.