Pedro De‐la‐Torre

Identification of Druggable Binding Sites and Small Molecules as Modulators of TMC1

The paper identifies small molecule modulators of TMC1 channels using structure-based screening and validates their effects on dye uptake in cochlear explants.

PKHD1L1 is required for stereocilia bundle maintenance, durable hearing function and resilience to noise exposure.

This study shows PKHD1L1 is essential for maintaining stereocilia bundles, hearing function, and resilience to noise in mice, with loss leading to age-related hearing loss and susceptibility to noise damage.

Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 Proteins

The paper identifies elasticity and thermal stability as critical factors determining the effectiveness of mini-protocadherin-15 proteins in rescuing hearing in USH1F mouse models.

PKHD1L1, A Gene Involved in the Stereocilia Coat, Causes Autosomal Recessive Nonsyndromic Hearing Loss

This study identifies PKHD1L1 as a cause of autosomal recessive nonsyndromic hearing loss through exome sequencing and functional analysis in human families and animal models.