Artur A. Indzhykulian

Disruption of a Structural Niche for Otoconia Maintenance May Underlie Common Vestibular Disorders

The paper identifies a structural niche in the inner ear responsible for otoconia maintenance and links its disruption to vestibular disorders.

Frem2 Knockout Mice Exhibit Fraser Syndrome Phenotypes and Neonatal Lethality Due to Bilateral Renal Agenesis

Identification of Druggable Binding Sites and Small Molecules as Modulators of TMC1

The paper identifies small molecule modulators of TMC1 channels using structure-based screening and validates their effects on dye uptake in cochlear explants.

PKHD1L1 is required for stereocilia bundle maintenance, durable hearing function and resilience to noise exposure.

This study shows PKHD1L1 is essential for maintaining stereocilia bundles, hearing function, and resilience to noise in mice, with loss leading to age-related hearing loss and susceptibility to noise damage.

VASCilia (Vision Analysis StereoCilia): A Napari Plugin for Deep Learning-Based 3D Analysis of Cochlear Hair Cell Stereocilia Bundles

VASCilia is a Napari plugin that uses deep learning to analyze 3D cochlear hair cell stereocilia bundles, revealing biological insights about actin content and bundle organization.

Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 Proteins

The paper identifies elasticity and thermal stability as critical factors determining the effectiveness of mini-protocadherin-15 proteins in rescuing hearing in USH1F mouse models.

Large-scale annotated dataset for cochlear hair cell detection and classification

The paper presents a large annotated dataset of cochlear hair cells for machine learning applications in hearing research.

PKHD1L1, A Gene Involved in the Stereocilia Coat, Causes Autosomal Recessive Nonsyndromic Hearing Loss

This study identifies PKHD1L1 as a cause of autosomal recessive nonsyndromic hearing loss through exome sequencing and functional analysis in human families and animal models.

SKOOTS: Skeleton oriented object segmentation for mitochondria

SKOOTS segments mitochondria in 3D imaging data efficiently, revealing structural changes not detectable with existing methods.

The Hair Cell Analysis Toolbox: A machine learning-based whole cochlea analysis pipeline

The paper introduces HCAT, a machine learning tool for automated analysis of hair cells in cochlear images, enabling fast and unbiased counting, classification, and cochleogram generation.

Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish

This study shows mechanical overstimulation causes acute injury and synapse loss in zebrafish neuromasts, but recovery occurs rapidly.