Gating mechanism of human N-type voltage-gated calcium channel
Yanli Dong, Yiwei Gao, Shuai Xu, Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Yuan Tian, Bei Yang, Xuejun Cai Zhang, Daohua Jiang, Zhuo Huang, Yan Zhao
The paper presents a cryo-EM structure of the human CaV2.2 complex, revealing the closed-state inactivation mechanism through the blocking-ball formed by the W-helix.
Cell Reports · Nov 1, 2021Peer-reviewedNeuroscience