Author

Shuai Xu

Peking UniversityORCID 0000-0002-6502-7138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Yuan TianiD· 2 shared Zhuo HuangiD· 2 shared Bei YangiD· 1 shared Bin LiiD· 1 shared Chao PengiD· 1 shared Daohua JiangiD· 1 shared Fan YangiD· 1 shared Guifang Duan· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Yuan TianORCID

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2 papers

Recent·Most cited

Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

Yuan Tian, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, , Zhuo Huang

The paper identifies a functional coupling between Slack and NaV1.6 that enhances quinidine blockade of Slack, suggesting a new approach for treating KCNT1-related epilepsy.

eLife · May 31, 2023Peer-reviewedNeuroscience

Gating mechanism of human N-type voltage-gated calcium channel

Yanli Dong, Yiwei Gao, Shuai Xu, Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Yuan Tian, Bei Yang, Xuejun Cai Zhang, Daohua Jiang, Zhuo Huang, Yan Zhao

The paper presents a cryo-EM structure of the human CaV2.2 complex, revealing the closed-state inactivation mechanism through the blocking-ball formed by the W-helix.

Cell Reports · Nov 1, 2021Peer-reviewedNeuroscience