This study shows that combining CD73 and RAS(ON) inhibition reduces tumor growth and immune suppression in pancreatic cancer by targeting KRAS-MAPK driven CD73 signaling.

bioRxiv · Oct 25, 2026 · PreprintCancer Biology

Pulsed Field Ablation Enables Stromal Manipulation and Tumor Reduction in Pancreatic Ductal Adenocarcinoma

MacKenzie V. Demmel, Lincoln N. Strickland, Kyle L. McAndrews, Khadija Shahab Turabi, AR Waller, Shwetapadma Dash, Urvinder Kaur Sardarni, Nirav C Thosani, Raju Viswanathan, Jennifer M. Bailey

This study shows pulsed field ablation (PFA) reduces tumor growth in a mouse model of pancreatic ductal adenocarcinoma by altering the tumor microenvironment and stromal cells.

bioRxiv · Oct 7, 2026 · PreprintBioengineering

Combination Immunotherapy Enhances Serial Radiofrequency Ablation Induced Systemic Antitumor Immunity in Pancreatic Cancer

Lincoln N. Strickland, MacKenzie V. Demmel, Wendao Liu, AR Waller, Shwetapadma Dash, Khadija Shahab Turabi, Urvinder Kaur Sardarni, Nicolette R. Mardik, Casey Van Kirk, Baylee J. O’Brien, Julie Rowe, Putao Cen, Kelsey A. Klute, Jesse L. Cox, Zhongming Zhao, , Jennifer M. Bailey

This study shows combination immunotherapy enhances systemic antitumor immunity induced by serial radiofrequency ablation in pancreatic cancer by targeting CD73, PD-L1, and CSF1R.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology