Kelsey A. Klute

Oncogenic KRAS-MAPK signaling sustains a CD73 dependent therapeutic vulnerability in pancreatic cancer

This study shows that combining CD73 and RAS(ON) inhibition reduces tumor growth and immune suppression in pancreatic cancer by targeting KRAS-MAPK driven CD73 signaling.

Combination Immunotherapy Enhances Serial Radiofrequency Ablation Induced Systemic Antitumor Immunity in Pancreatic Cancer

This study shows combination immunotherapy enhances systemic antitumor immunity induced by serial radiofrequency ablation in pancreatic cancer by targeting CD73, PD-L1, and CSF1R.

AI-powered Deep Visual Proteomics reveals critical molecular transitions in pancreatic cancer precursors

This study uses AI-driven proteomics to identify molecular transitions in pancreatic cancer precursors, revealing early molecular changes in histologically normal tissue.

Dietary Fat Content Influences PanIN Progression and Pancreatic Cancer Development in Mice

This study shows that ketogenic and high-fat diets accelerate pancreatic cancer progression in mice, leading to more aggressive tumors and a pro-inflammatory microenvironment.

An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia

This study identifies an iron-regulated signaling pathway involving MSRA and PKA that drives adipose browning and cancer cachexia, showing that MsrA deletion reduces cachexia in PDA models.

Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.