Molecular basis of Siglec-10 ligand recognition and antibody blockade
Klaudia Sobczak, Asier Antoñana-Vildosola, Pablo Valverde, Eunate Valdaliso-Díez, Amaia Mentxaka, Maria Alejandra Travecedo, Zeinab Jame-Chernaboo, Edward N. Schmidt, Larissa Heinze, Silvia D’Andrea, Iker Oyenarte, Maria Elena Laugieri, Maju Joe, Fahima Mozaneh, Sung-Yao Lin, , June Ereño‐Orbea
This study identifies key residues in Siglec-10 involved in ligand recognition and shows that antibody blockade can restore CAR-T cell cytotoxicity.
bioRxiv · Jun 10, 2025 · PreprintMolecular Biology