This study identifies CD11b as a noncanonical marker of cytotoxic competence in CD8+ T cells, enhancing their antitumor activity in mouse and human tumors.

bioRxiv · Oct 14, 2026 · PreprintImmunology

Molecular basis of Siglec-10 ligand recognition and antibody blockade

Klaudia Sobczak, Asier Antoñana-Vildosola, Pablo Valverde, Eunate Valdaliso-Díez, Amaia Mentxaka, Maria Alejandra Travecedo, Zeinab Jame-Chernaboo, Edward N. Schmidt, Larissa Heinze, Silvia D’Andrea, Iker Oyenarte, Maria Elena Laugieri, Maju Joe, Fahima Mozaneh, Sung-Yao Lin, , June Ereño‐Orbea

This study identifies key residues in Siglec-10 involved in ligand recognition and shows that antibody blockade can restore CAR-T cell cytotoxicity.

bioRxiv · Jun 10, 2025 · PreprintMolecular Biology

The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

Florent Sauvé, Sreekala S. Nampoothiri, Sophie A. Clarke, Daniela Fernandois, Caio Fernando Ferreira Coêlho, Julie Dewisme, Edouard Mills, Gaëtan Ternier, Ludovica Cotellessa, Cristina Iglesias, Helge Müller‐Fielitz, Thibaud Lebouvier, Romain Perbet, V. Florent, Marc Baroncini, , Vincent Prévot

The paper investigates SARS-CoV-2 infection in the hypothalamus and associated regions, showing viral entry receptors and susceptibility factors linked to neurological symptoms in COVID-19.

EBioMedicine · Sep 13, 2023Peer-reviewedNeuroscience