Paula Restrepo

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

The paper constructs a spatial transcriptomic atlas of human skin, identifying 45 cell types across 15 sites and revealing neighborhood disruptions in disease.

The paper identifies a three-gene expression signature that predicts response to selinexor in multiple myeloma and glioblastoma.

GeTallele estimates and compares variant read probabilities in DNA and RNA sequencing data to assess allele asymmetries and genomic events.