Metastasis-associated wound repair promotes reciprocal activation of the lung epithelium and breast cancer metastases during outgrowth
Jessica L. Christenson, Nicole S. Spoelstra, Michelle M. Williams, Kathleen I. O’Neill, David J. Orlicky, Jennifer A. Wagner, Andrew E. Goodspeed, Li‐Wei Kuo, Lyndsey S. Crump, Jennifer K. Richer
This study shows that lung epithelial cells promote breast cancer metastasis through wound repair mechanisms, and targeting CREB signaling with PDE4 inhibitors can reduce metastatic outgrowth.
bioRxiv · Jul 23, 2025 · PreprintCancer Biology