Author

Matthew P. Thompson

Northwestern UniversityORCID 0000-0002-0428-291XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Nathan C. GianneschiiD· 2 shared Andrew P. LonghiniiD· 1 shared Austin DuBoseiD· 1 shared Baofu QiaoiD· 1 shared Clara BarbutiD· 1 shared Colby Fagan· 1 shared Diwakar ShuklaiD· 1 shared Dylan Nakamura· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Nathan C. GianneschiORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 6, 2026

β-Hairpin Fold Peptide Brush Polymers

Julia Oktawiec, Hassan Nadeem, Omar M. Ebrahim…·Nathan C. Gianneschi

This study examines peptide-brush polymers mimicking protein structure, finding that polymer backbones disrupt secondary structures and alter free-energy landscapes.

DOI 10.64898/2026.10.02.756272

statistical modelsimulation

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 2, 2025

Protein-Like Polymer for Inhibition of Tau Fibril Propagation in Human-Derived Models of Neurodegeneration

Andrew P. Longhini, Mara A. Fattah, Julia Sala‐Jarque…·Kenneth S. Kosik

This paper develops a protein-like polymer that inhibits tau fibril propagation in human-derived models of neurodegeneration by targeting a specific structural motif of 4R tau isoforms.

DOI 10.1101/2025.02.02.636155

humanprotein structure

𝕏 PostBluesky