Li Shen

Targeting synthetic lethality between non-homologous end joining and radiation in very high-risk SHH medulloblastoma

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications

The paper identifies a rapid increase in the SARS-CoV-2 M gene mutation I82T and its association with a new sub-B.1 clade, suggesting potential biological fitness and implications for surveillance.

Comprehensive variant and haplotype landscapes of 50,500 global SARS-CoV-2 isolates and accelerating accumulation of country-private variant profiles

The paper analyzes 50,500 SARS-CoV-2 isolates to map global variant and haplotype landscapes, identifying country-private variants and haplotypes that increased with travel restrictions.

Children's Hospital Los Angeles COVID-19 Analysis Research Database (CARD) - A Resource for Rapid SARS-CoV-2 Genome Identification Using Interactive Online Phylogenetic Tools

The paper introduces CARD, a database for SARS-CoV-2 genomic surveillance, enabling rapid variant identification and phylogenetic analysis of viral isolates.

Highly sensitive and full-genome interrogation of SARS-CoV-2 using multiplexed PCR enrichment followed by next-generation sequencing

A 343-primer-pair multiplex PCR assay enables electrophoretic detection and full-genome sequencing of SARS-CoV-2 across 8 to half a million viral copies from 13 clinical specimens.