Targeting synthetic lethality between non-homologous end joining and radiation in very high-risk SHH medulloblastoma
Alexandria DeCarlo, Graham Dickson and Hugh MacLeod, Carolina Fernandes da Silva, Li Shen, Julija Povilaikaite, Madeline Deane, Lucas Aragao, Mariska Sie, Deborah Termini, Jonathan Magee, Brian L. Gudenas, Sneha Sukumaran, Frédéric Charron, Richard C. Marcellus, Rima Al‐awar, , Vijay Ramaswamy
This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.
Cell Reports Medicine · Jun 24, 2025Peer-reviewedCancer Biology