Author

Brian L. Gudenas

St. Jude Children's Research HospitalORCID 0000-0002-9487-0300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CUT&Tag· 1 Approach:deep learning· 1

Frequent Co-Authors

Paul A. NorthcottiD· 3 shared Michael D. TayloriD· 2 shared Ahmed M. AmaniD· 1 shared Alexandre Gaspar‐MaiaiD· 1 shared Alexandria DeCarlo· 1 shared Amarine Trolat· 1 shared Carolina Fernandes da SilvaiD· 1 shared Carolina Nör· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Paul A. NorthcottORCID

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Author profile →

3 papers

Recent·Most cited

Human stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscape.

Zulekha A. Qadeer, Elise Hou, Dara Siegel, Samantha Westelman, Brian L. Gudenas, Kyle Smith, Wazim Mohammed Ismail, Linyu Wang, Mackenzie Johnson, Shane Grele, Ronald Phua, Liam D. Hendrikse, Ekin Güney, Miller Huang, Alexandre Gaspar‐Maia, , William A. Weiss

bioRxiv · Dec 8, 2025 · PreprintCancer Biology

Ras-Responsive Element Binding Protein 1 regulates survival of Group 3 medulloblastoma

Meher Beigi Masihi, Kendall R. Chambers, Richard A. Friedman, Sergey Pampou, Brian L. Gudenas, Jacob Torrejon-Diaz, Catherine A. A. Lee, Grace Furnari, Lianne Q. Chau, Sajina GC, Yingxi Lin, Owen S. Chapman, Patryk Skowron, Livia Garzia, Michael D. Taylor, , Robert J. Wechsler‐Reya

This study identifies RREB1 as a key driver of Group 3 medulloblastoma, showing its role in tumor growth and survival through the c-MET signaling pathway.

bioRxiv · Jul 16, 2025 · PreprintCancer Biology

Targeting synthetic lethality between non-homologous end joining and radiation in very high-risk SHH medulloblastoma

Alexandria DeCarlo, Graham Dickson and Hugh MacLeod, Carolina Fernandes da Silva, Li Shen, Julija Povilaikaite, Madeline Deane, Lucas Aragao, Mariska Sie, Deborah Termini, Jonathan Magee, Brian L. Gudenas, Sneha Sukumaran, Frédéric Charron, Richard C. Marcellus, Rima Al‐awar, , Vijay Ramaswamy

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

Cell Reports Medicine · Jun 24, 2025Peer-reviewedCancer Biology