Fereshteh Torabi

The paper builds a spatiotemporal map of human pilosebaceous unit development using single-cell multiomics and machine learning, showing how epithelial-mesenchymal interactions drive organogenesis and how sebaceous gland programs are disrupted in tumors.

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

PerturbGen predicts how genetic perturbations affect cellular trajectories across time in human datasets, showing effects on immune responses, hematopoiesis, and skin development.

The paper identifies Polycomb-regulated gene expression and chromatin state differences in iPSCs that correlate with differentiation efficiency.

The paper identifies non-canonical enhancers in human pluripotent stem cells that lack typical enhancer features but regulate gene expression and cell fate.

The paper identifies epigenetically primed enhancers in early embryonic development and shows their role in regulating developmental gene networks across species.

The paper identifies Th2-like malignant cells in CTCL supported by a B cell-rich microenvironment through single-cell and spatial transcriptomics analysis.

This study creates a prenatal human skin cell atlas, revealing immune cells' role in skin development and showing their impact on vascular and hair follicle formation.