Stiffness-dependent LOX regulation via HIF-1 drives extracellular matrix modifications in psoriasis
Parvaneh Balsini, Pauline Weinzettl, David Samardzic, Nina Zila, Maria Buchberger, Christian Freystätter, Philipp Tschandl, Matthias Wielscher, Wolfgang Weninger, Karin Pfisterer
This study identifies stiffness-dependent LOX regulation via HIF-1 in psoriasis, linking ECM modifications to disease progression through mechanosensitive fibroblasts.
Journal of Investigative Dermatology · Nov 26, 2024Peer-reviewedCell Biology