Gary Reynolds

A Community-Driven Single-Cell PBMC Reference Integrating Landmark Datasets Spanning Health and Disease

HARP integrates PBMC data from multiple studies to create a reference atlas with consensus annotations and identifies age, sex, and disease-related cellular modules.

Chemokine Landscapes of the Tumor Microenvironment

The paper maps chemokine landscapes in solid tumors using spatial transcriptomics, identifying conserved and tumor-specific patterns and revealing perivascular CCR7 dendritic cells as key sources of lymphocyte-attracting chemokines.

Building optimized single-cell reference atlases with scAtlasTb

The paper introduces scAtlasTb, a framework for building and optimizing single-cell reference atlases, demonstrating its application on three Human Cell Atlas projects.

Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha.

This study identifies non-canonical NF-κB signalling as a therapeutic target in CYLD cutaneous syndrome and shows that IKK inhibition reduces tumor viability in patient-derived models.

Cutaneous T cell lymphoma atlas reveals malignant Th2 cells supported by a B cell-rich microenvironment

The paper identifies Th2-like malignant cells in CTCL supported by a B cell-rich microenvironment through single-cell and spatial transcriptomics analysis.

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

This study creates a prenatal human skin cell atlas, revealing immune cells' role in skin development and showing their impact on vascular and hair follicle formation.

Mapping interindividual dynamics of innate immune response at single-cell resolution

The paper develops GASPACHO to identify dynamic eQTLs in antiviral responses using single-cell RNA-seq, uncovering thousands of eQTLs and linking them to disease risk loci.

Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

A single cell atlas of human cornea that defines its development, limbal stem and progenitor cells and the interactions with the limbal niche

This paper generates a single-cell atlas of the human cornea across development and disease, identifying key cell types, markers, and interactions that inform stem cell maintenance and disease mechanisms.

Decoding the development of the blood and immune systems during human fetal liver haematopoiesis

The paper uses single-cell transcriptomics to map hematopoiesis in human fetal liver, identifying cell differentiation trajectories and shifts in hematopoietic composition during development.