Author

Tianchen Li

The University of SydneyORCID 0009-0002-5685-9001Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Yi SheniD· 2 shared Abel AnwariD· 1 shared Brayden Williams· 1 shared Margaret SundeiD· 1 shared Megan C. SteainiD· 1 shared Qi HaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

Yi ShenORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 18, 2026

A conformational switch governs the dual role of liquid-liquid phase separation in amyloid fibrillization

Tianchen Li, Brayden Williams, Qi Han…·Yi Shen

This study shows that the conformational state of RIPK3 RHIM domain determines whether it forms reversible condensates or amyloid fibrils, revealing a dual role for phase separation in amyloid formation.

DOI 10.64898/2026.09.12.751119

protein structureexperimental assay

𝕏 PostBluesky

BioengineeringACS Applied Materials & InterfacesPeer-reviewedJun 18, 2025

Thermal cycling resets the irreversible liquid-to-solid transition of peptide condensates during aging

Abel Anwar, Tianchen Li, Yi Shen

This study shows thermal cycling can delay irreversible fiber formation in aged biomolecular condensates and preserve their stability.

5 citations

proteomicsexperimental assay

𝕏 PostBluesky