Author

Brayden Williams

The University of Sydney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

Margaret SundeiD· 2 shared Megan C. SteainiD· 2 shared Ann E. McDermottiD· 1 shared Chengming HeiD· 1 shared Chi L.L. PhamiD· 1 shared Crystal Semaan· 1 shared Emma SiereckiiD· 1 shared Eric G. KeeleriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Margaret SundeORCID

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2 papers

Recent·Most cited

A conformational switch governs the dual role of liquid-liquid phase separation in amyloid fibrillization

Tianchen Li, Brayden Williams, Qi Han, Megan C. Steain, Margaret Sunde, Yi Shen

This study shows that the conformational state of RIPK3 RHIM domain determines whether it forms reversible condensates or amyloid fibrils, revealing a dual role for phase separation in amyloid formation.

bioRxiv · Sep 18, 2026 · PreprintBiophysics

Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

Chengming He, Nikhil R. Varghese, Eric G. Keeler, Chi L.L. Pham, Teng Xie, Brayden Williams, Stephan Tetter, Crystal Semaan, Karyn L. Wilde, Simon H. J. Brown, James C. Bouwer, Yann Gambin, Emma Sierecki, Megan C. Steain, Ruhong Zhou, , Ann E. McDermott

This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.

Proceedings of the National Academy of Sciences · Apr 27, 2026Peer-reviewedBiophysics