This study links the developmental expression of risk genes to the age of onset of neuropsychiatric disorders, showing that disease peaks align with gene expression peaks in the prefrontal cortex.

bioRxiv · Aug 27, 2025 · PreprintGenetics

Patterns of convergence and divergence between bipolar disorder type I and type II: evidence from integrative genomic analyses

Yunqi Huang, Yunjia Liu, Yulu Wu, Yiguo Tang, Siyi Liu, Liling Xiao, M Zhang, Shiwan Tao, Min Xie, Minhan Dai, Mingli Li, Hongsheng Gui, Qiang Wang

This study identifies shared and distinct genetic loci between bipolar disorder type I and II using integrative genomic analyses, revealing convergence and divergence in their genetic structures.

Frontiers in Cell and Developmental Biology · Jul 15, 2022Peer-reviewedGenetic & Genomic Medicine

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

Alexander G. Bick, Joshua S. Weinstock, Satish Kumar Nandakumar, Charles P. Fulco, Matthew Joseph Leventhal, Erik L. Bao, Joseph Nasser, Seyedeh Maryam Zekavat, Mindy D Szeto, Cecelia A. Laurie, Margaret A. Taub, Braxton D. Mitchell, Kathleen C. Barnes, Arden Moscati, Myriam Fornage, , Eric Boerwinkle

The paper identifies germline genetic variants associated with clonal hematopoiesis of indeterminate potential (CHIP) using whole genome sequences from the TOPMed program.

bioRxiv · Sep 27, 2019 · PreprintGenomics

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

Annah B. Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N. Nguyen, Lies Lahousse, Jeanne C. Latourelle, Albert V. Smith, Traci M. Bartz, Mary Furlan Feitosa, Wei Dong Gao, Tarunveer S. Ahluwalia, Wenbo Tang, Christopher J. Oldmeadow, Qing Duan, , Josée Dupuis

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.

Nature Communications · Jul 24, 2018Peer-reviewedGenetics