Min Xie

Interstitial macrophages prevent tuberculosis relapse by restricting Mycobacterium tuberculosis immune evasion

This study shows that interstitial macrophages prevent tuberculosis relapse by restricting Mtb immune evasion during latent infection.

Hypobaric hypoxia drives citrate cycle reprogramming to suppress tumor progression

This study shows hypobaric hypoxia suppresses tumor progression by reprogramming the citrate cycle and inhibiting the HIF-1 pathway, enhancing antitumor immune response and improving therapy outcomes.

Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease

The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.

CellBin: a highly accurate single-cell gene expression processing pipeline for high-resolution spatial transcriptomics

CellBin processes high-resolution spatial transcriptomics data to generate accurate single-cell gene expression profiles, improving accuracy and efficiency in mouse brain tissue analysis.

Patterns of convergence and divergence between bipolar disorder type I and type II: evidence from integrative genomic analyses

This study identifies shared and distinct genetic loci between bipolar disorder type I and II using integrative genomic analyses, revealing convergence and divergence in their genetic structures.