The paper quantifies enhancer activity dynamics in mESCs during differentiation using FAIRE-STARR-seq, identifying features that predict enhancer activity and reveal regulatory insights.

Nucleic Acids Research · Oct 22, 2021Peer-reviewedGenomics

Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites

Marina Kulik, Melissa Bothe, Gözde Kibar, Alisa Fuchs, Stefanie Schöne, Stefan Preković, Isabel Mayayo‐Peralta, Ho‐Ryun Chung, Wilbert T. Zwart, Christine Helsen, Frank Claessens, Sebastiaan H. Meijsing

This study identifies mechanisms by which androgen and glucocorticoid receptors achieve functional diversification through distinct DNA binding and downstream regulatory events.

Nucleic Acids Research · Mar 12, 2021Peer-reviewedGenomics

CRUP: A comprehensive framework to predict condition-specific regulatory units

Anna Ramisch, Verena Heinrich, Laura V. Glaser, Alisa Fuchs, Xinyi Yang, Philipp Benner, Robert Schöpflin, Na Li, Sarah Kinkley, Anja Römer-Hillmann, John Longinotto, Steffen Heyne, Beate Czepukojc, Sonja M. Kessler, Alexandra K. Kiemer, , Martin Vingron

CRUP predicts condition-specific regulatory units by analyzing histone modification ChIP-seq data and linking enhancers to target genes in rheumatoid arthritis.

Genome biology · Nov 7, 2019Peer-reviewedBioinformatics