LCM-FFPEseq enables high-sensitivity transcriptomics from FFPE tissues with single-cell resolution, detecting over 14,000 genes per sample using as few as 30 cells.

Scientific Reports · Sep 1, 2026Peer-reviewedGenomics

Variant curation of the largest compendium of FOXL2 coding and non-coding sequence and structural variants in BPES

Charlotte Matton, Julie Van De Velde, Marieke De Bruyne, Stijn Van de Sompele, Sally Hooghe, Hannes Syryn, Miriam Bauwens, Eva D’haene, Annelies Dheedene, Martine Cools, Shoko Komatsuzaki, Ewelina Preizner-Rzucidło, Alison Ross, Christine Armstrong, Wendy Watkins, , Elfride B. W. De Baere

The paper curates and classifies the largest compendium of FOXL2 sequence and structural variants in BPES, identifying key mutational patterns and improving diagnostic and genetic counseling.

Human Mutation · Jan 1, 2026Peer-reviewedGenetic & Genomic Medicine

TurboID proximity interactome mapping reveals NR2E3 association with AP-1 and retinal developmental complexes

Edith De Bruycker, Olivier Zwaenepoel, George D. Moschonas, Delphine De Sutter, Eva D’haene, Charlotte Matton, Laure Vandevelde, Julie Van De Velde, Quinten Mahieu, Sara Dufour, Delphi Van Haver, Louis Delhaye, Simon Devos, Frauke Coppieters, Sven Eyckerman, , Elfride B. W. De Baere

This study maps the proximity interactome of NR2E3 and its G56R variant using TurboID, revealing interactions with retinal development complexes and identifying BCOR as enriched in the mutant network.

bioRxiv · Sep 4, 2025 · PreprintSystems Biology