Nadeen O. Chahine

The paper shows that muscle contraction regulates TGFβ signaling and epitenon formation during embryonic tendon development, leading to structural and functional deficits in paralyzed tendons.

This study shows that modulating RhoA signaling in NP cells can restore NP-like gene expression and morphology in 2D and 3D cultures, with effects dependent on the microenvironment.

This study shows HMGB1 promotes macrophage recruitment and worsens intervertebral disc degeneration after injury, with knockout mice showing reduced mechanical and structural damage.

This study shows that adult zebrafish can regenerate functional synovial joints after complete removal, revealing a multipotent cell source and regenerative programs.