Retrograde trafficking inhibitors allosterically trap Get3 to block tail-anchored protein biogenesis
Juliet A. Lee, Xilin Gu, Charlene Chan, Vida Storm Robertson, Victor Garcia-Ruiz, Yancheng E. Li, Anna Huyen Ngo, Philip Alabi, Vladimir Denic, Jason K. Sello, William Clemons
This study identifies Retro-1 and Retro-2 as inhibitors that trap Get3, blocking tail-anchored protein biogenesis by stabilizing a stalled complex.
bioRxiv · Jul 13, 2026 · PreprintBiochemistry