Yancheng E. Li

Retrograde trafficking inhibitors allosterically trap Get3 to block tail-anchored protein biogenesis

This study identifies Retro-1 and Retro-2 as inhibitors that trap Get3, blocking tail-anchored protein biogenesis by stabilizing a stalled complex.

The structure of the lipid II flippase from monoderm bacteria

The paper reports structures of Staphylococcus aureus MurJ in different conformational states, revealing insights into its lipid II flipping mechanism and differences between monoderm and diderm bacteria.

Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics

The paper determines cryo-EM structures of APPB bound to MraY and DPAGT1, revealing conformational differences that guide the design of selective therapeutics for antibacterial and anticancer applications.

Nucleotide and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA

This study reports cryo-EM structures of ArsA, an ATPase involved in arsenite efflux, showing conformational changes driven by nucleotides and AsIII binding.

Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

The paper identifies minimal somatic hypermutations required for CD4bs bNAb neutralization breadth and uses structural data to guide HIV-1 vaccine immunogen design.