William Clemons

This paper develops chemically stable tunicamycin analogues that inhibit DPAGT1 selectively with reduced toxicity and improved pharmacokinetics.

This study identifies Retro-1 and Retro-2 as inhibitors that trap Get3, blocking tail-anchored protein biogenesis by stabilizing a stalled complex.

The paper reports structures of Staphylococcus aureus MurJ in different conformational states, revealing insights into its lipid II flipping mechanism and differences between monoderm and diderm bacteria.

The paper reports cryo-EM structures of ArsB, revealing its mechanism of metalloid transport and H+/metalloid antiport.

The paper determines cryo-EM structures of APPB bound to MraY and DPAGT1, revealing conformational differences that guide the design of selective therapeutics for antibacterial and anticancer applications.

This study reports cryo-EM structures of ArsA, an ATPase involved in arsenite efflux, showing conformational changes driven by nucleotides and AsIII binding.

This paper develops a statistical model called IMProve to predict membrane protein expression in E. coli using sequence information, significantly increasing the success rate of expression trials.