Maria‐Elena Torres‐Padilla

This study shows ERH maintains H3K9me3 heterochromatin in mammalian cells, restricting lineage potential and repressing pluripotency genes during development and reprogramming.

This study identifies Aquarius RNA helicase as essential for maintaining genomic resilience and pluripotent stem cell identity by resolving transcription-replication conflicts.

CIARA identifies markers of rare cell types from single-cell RNA-seq data, outperforming existing methods and discovering new cell populations in mouse and human samples.

This study identifies EZHIP as a novel cofactor of PRC2 that limits its activity in germ cells, leading to altered H3K27me2/3 deposition and impaired fertility in female mice.

Hi-C in 2-cell-like mouse cells ties MERVL retroelement transcription to transient insulating domain boundaries, with insertions differing between strains, placing retroelements at the origin of embryonic genome architecture.