Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimers disease mouse model
Alex Orlowski, Joseph Karippaparambil, Jean‐Michel Paumier, Shraddha Ghanta, Eduardo Pallares, Rumamol Chandran, Daisy Edmison, Jamuna Tandukar, Ruixuan Gao, Swetha Gowrishankar
The paper shows that loss of AP-4 complex function causes axonal lysosome buildup, which worsens amyloid plaque pathology and gliosis in an Alzheimer's disease mouse model.
eNeuro · Dec 1, 2024Peer-reviewedCell Biology